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    CG42340 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 7354472, updated on 10-May-2024

    Summary

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    Official Symbol
    CG42340provided by FlyBase
    Primary source
    FLYBASE:FBgn0259242
    Locus tag
    Dmel_CG42340
    See related
    AllianceGenome:FB:FBgn0259242
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12543; CG3367; Dmel\CG42340
    Old locus tag
    Dmel_CG12543; Dmel_CG3367
    Summary
    Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be integral component of plasma membrane. Is expressed in organism. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    6A1-6B1; 1-17 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6423123..6524323, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6317156..6418356, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Phenylalanine-GAA 1-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Alanine-glyoxylate aminotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel Drosophila two-pore domain K channels: rescue of channel function by heteromeric assembly. Döring F, et al. Eur J Neurosci, 2006 Oct. PMID 17074048
    2. Drug induces depression-like phenotypes and alters gene expression profiles in Drosophila. Jiang MD, et al. Brain Res Bull, 2017 Jun. PMID 28625786
    3. Operation of a homeostatic sleep switch. Pimentel D, et al. Nature, 2016 Aug 18. PMID 27487216, Free PMC Article
    4. The Drosophila Small Conductance Calcium-Activated Potassium Channel Negatively Regulates Nociception. Walcott KCE, et al. Cell Rep, 2018 Sep 18. PMID 30231996, Free PMC Article
    5. The Genomic Basis of Postponed Senescence in Drosophila melanogaster. Carnes MU, et al. PLoS One, 2015. PMID 26378456, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c6435212-6430043 mobile_element_type = transposon:Rt1b{}71
    • Loc: c6451058-6445358 mobile_element_type = transposon:297{}72

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42340-PB
    CG42340-PC
    CG42340-PD
    CG42340-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6423123..6524323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272346.1 → NP_001259275.1  uncharacterized protein Dmel_CG42340, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259275.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0W7, Q29R21
      Conserved Domains (1) summary
      pfam07885
      Location:208 → 264
      Ion_trans_2; Ion channel

    2. NM_001144693.2 → NP_001138165.1  uncharacterized protein Dmel_CG42340, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138165.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0W7, Q29R21
      Conserved Domains (1) summary
      pfam07885
      Location:208 → 264
      Ion_trans_2; Ion channel

    3. NM_001382086.1 → NP_001368973.1  uncharacterized protein Dmel_CG42340, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EDG1
      Conserved Domains (1) summary
      pfam07885
      Location:208 → 264
      Ion_trans_2; Ion channel

    4. NM_132093.3 → NP_572321.3  uncharacterized protein Dmel_CG42340, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572321.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY17
      Conserved Domains (2) summary
      pfam00520
      Location:376 → 453
      Ion_trans; Ion transport protein
      pfam07885
      Location:208 → 264
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EDG1 A0A6H2EDG1
    B7Z0W7 B7Z0W7
    R9PY17 R9PY17

    Gene LinkOut

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